Version 5.4
Bos taurus Gene: BT.57494
Summary
InnateDB Gene IDBG-631864.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.57494
Gene Name beta-adducin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009076
Encoded Proteins
IDBP-683431
beta-adducin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075340:
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:13698135-13755248
Strand Forward strand
Band
Transcripts
ENSBTAT00000011966 ENSBTAP00000011966
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0030507 spectrin binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051015 actin filament binding
Biological Process
GO:0006461 protein complex assembly
GO:0030097 hemopoiesis
GO:0032092 positive regulation of protein binding
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0005856 cytoskeleton
GO:0008290 F-actin capping protein complex
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000075340
View Gene Order
ENSMUSG00000030000
View Gene Order
Cross-References
SwissProt
TrEMBL F1MXA4
UniProt Splice Variant
Entrez Gene 518896
UniGene Bt.57494
RefSeq NM_001099009 XM_005212527 XM_005212528
HUGO HGNC:244
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030414
GenPept
RNA Seq Atlas 518896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca