InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.105012

Summary

InnateDB Gene

IDBG-632267.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105012

Gene Name

homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016896

Encoded Proteins

IDBP-683885

homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051108:
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:25048853-25059249

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022472

ENSBTAP00000022472

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006986	response to unfolded protein
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031396	regulation of protein ubiquitination
GO:0032092	positive regulation of protein binding