InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SCN3B

Summary

InnateDB Gene

IDBG-632273.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN3B

Gene Name

Sodium channel subunit beta-3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016768

Encoded Proteins

IDBP-683877

Sodium channel subunit beta-3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166257:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:34769329-34791462

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022302

ENSBTAP00000022302

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0010460	positive regulation of heart rate
GO:0010765	positive regulation of sodium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0051899	membrane depolarization
GO:0060048	cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0072659	protein localization to plasma membrane
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086010	membrane depolarization during action potential
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086070	SA node cell to atrial cardiac muscle cell communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000166257

View Gene Order

ENSMUSG00000049281

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.62049

RefSeq

NM_001046495

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas