InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.70631

Summary

InnateDB Gene

IDBG-632306.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.70631

Gene Name

annexin A1

Synonyms

p35

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015978

Encoded Proteins

IDBP-683914

annexin A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20679535

[Homo sapiens] ANXA1 is cleaved by CAPN1 to generate a N-terminally truncated form of ANXA1 shown to be anti-inflammatory and able to activate ERK. This C-terminal ANXA1 peptide functions by increasing ICAM1 clustering around adherent neutrophils to anchor them to the endothelium and promote transmigration through the transcellular route.

PMID 25533809

[Mus musculus] Anxa1-/- mice are more susceptible to Mycobacterium tuberculosis infection as evidenced by a transient increase in pulmonary bacterial burden, exacerbated and disorganized granulomatous inflammation and impaired ability of Anxa1-/- dendritic cells to activate naïve T cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135046:
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:49624473-49642916

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021256

ENSBTAP00000021256

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005198	structural molecule activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0019834	phospholipase A2 inhibitor activity
GO:0030674	protein binding, bridging
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001780	neutrophil homeostasis
GO:0007165	signal transduction
GO:0018149	peptide cross-linking
GO:0030216	keratinocyte differentiation
GO:0031340	positive regulation of vesicle fusion
GO:0033031	positive regulation of neutrophil apoptotic process
GO:0042127	regulation of cell proliferation
GO:0043086	negative regulation of catalytic activity
GO:0046632	alpha-beta T cell differentiation
GO:0050482	arachidonic acid secretion
GO:0071385	cellular response to glucocorticoid stimulus
GO:0097350	neutrophil clearance
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2000483	negative regulation of interleukin-8 secretion

Cellular Component

GO:0001533	cornified envelope
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0042383	sarcolemma
GO:0070062	extracellular vesicular exosome