InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MYOD1

Summary

InnateDB Gene

IDBG-632365.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYOD1

Gene Name

myoblast determination protein 1

Synonyms

MyoD

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002216

Encoded Proteins

IDBP-683971

myoblast determination protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129152:
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:35331401-35334046

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002868

ENSBTAP00000002868

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.

Predicted by orthology
Total	87 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0031625	ubiquitin protein ligase binding
GO:0035257	nuclear hormone receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007517	muscle organ development
GO:0007518	myoblast cell fate determination
GO:0007519	skeletal muscle tissue development
GO:0009267	cellular response to starvation
GO:0014904	myotube cell development
GO:0014908	myotube differentiation involved in skeletal muscle regeneration
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0043484	regulation of RNA splicing
GO:0043503	skeletal muscle fiber adaptation
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045445	myoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048741	skeletal muscle fiber development
GO:0051146	striated muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0071453	cellular response to oxygen levels
GO:1901741	positive regulation of myoblast fusion