InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADAR

Summary

InnateDB Gene

IDBG-632405.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAR

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007519

Encoded Proteins

IDBP-684037

adenosine deaminase, RNA-specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21809195

[Homo sapiens] ADAR destabalizes RNA structure by the deamination of adenosine to inosine, and therefore is able to disrupt replication of dsRNA viruses in the host.

PMID 21809195

[Mus musculus] Adar destabalizes RNA structure by the deamination of adenosine to inosine, and therefore is able to disrupt replication of dsRNA viruses in the host.

PMID 26335850

[Mus musculus] Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160710:
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:16033026-16052140

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009896

ENSBTAP00000009896

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006382	adenosine to inosine editing
GO:0006396	RNA processing
GO:0006606	protein import into nucleus
GO:0006611	protein export from nucleus
GO:0009615	response to virus
GO:0016553	base conversion or substitution editing
GO:0035455	response to interferon-alpha
GO:0043066	negative regulation of apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0051607	defense response to virus