Version 5.4
Bos taurus Gene: NKD2
Summary
InnateDB Gene IDBG-632438.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKD2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000034435
Encoded Proteins
IDBP-684052
naked cuticle homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145506:
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:71427335-71446013
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048774 ENSBTAP00000045759
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0010954 positive regulation of protein processing
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048210 Golgi vesicle fusion to target membrane
GO:0072661 protein targeting to plasma membrane
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145506
View Gene Order
ENSMUSG00000021567
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
wnt_canonical_pathway
Canonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_001256156
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca