InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.30106

Summary

InnateDB Gene

IDBG-632679.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.30106

Gene Name

mitotic spindle assembly checkpoint protein MAD2B

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013275

Encoded Proteins

IDBP-684308

mitotic spindle assembly checkpoint protein MAD2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116670:
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:42876001-42881565

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017655

ENSBTAP00000017655

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0005515	protein binding
GO:0008432	JUN kinase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001558	regulation of cell growth
GO:0006302	double-strand break repair
GO:0007015	actin filament organization
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042177	negative regulation of protein catabolic process
GO:0042772	DNA damage response, signal transduction resulting in transcription
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060564	negative regulation of mitotic anaphase-promoting complex activity
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin
GO:2000678	negative regulation of transcription regulatory region DNA binding