InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FBXO6

Summary

InnateDB Gene

IDBG-632683.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO6

Gene Name

F-box only protein 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014777

Encoded Proteins

IDBP-684311

F-box only protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116663:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:42881664-42899260

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000034170

ENSBTAP00000034071

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 128 interaction(s) predicted by orthology.

Predicted by orthology
Total	128 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006281	DNA repair
GO:0006516	glycoprotein catabolic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006986	response to unfolded protein
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process