Version 5.4
Bos taurus Gene: INTS3
Summary
InnateDB Gene IDBG-632723.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS3
Gene Name integrator complex subunit 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006235
Encoded Proteins
IDBP-684366
integrator complex subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143624:
INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:16685041-16724703
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008186 ENSBTAP00000008186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007093 mitotic cell cycle checkpoint
GO:0010212 response to ionizing radiation
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0032039 integrator complex
GO:0070876 SOSS complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143624
View Gene Order
ENSMUSG00000027933
View Gene Order
Cross-References
SwissProt
TrEMBL E1BN70
UniProt Splice Variant
Entrez Gene 511052
UniGene Bt.1389
RefSeq NM_001193087
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007178 DAAA02007179
GenPept
RNA Seq Atlas 511052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca