InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SOX6

Summary

InnateDB Gene

IDBG-632752.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX6

Gene Name

transcription factor SOX-6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000044185

Encoded Proteins

IDBP-684404

SRY (sex determining region Y)-box 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110693:
This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:36600420-37082361

Strand

Forward strand

Band

Transcripts

ENSBTAT00000061473

ENSBTAP00000053691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0016458	gene silencing
GO:0021778	oligodendrocyte cell fate specification
GO:0030097	hemopoiesis
GO:0030218	erythrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0042692	muscle cell differentiation
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048709	oligodendrocyte differentiation
GO:0048821	erythrocyte development
GO:0051216	cartilage development
GO:0055007	cardiac muscle cell differentiation
GO:0061036	positive regulation of cartilage development
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000741	positive regulation of mesenchymal stem cell differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000110693

View Gene Order

ENSMUSG00000051910

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.62052

RefSeq

NM_001191418 XM_005216028

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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