InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sox6

Summary

InnateDB Gene

IDBG-207342.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox6

Gene Name

SRY-box containing gene 6

Synonyms

AI987981; SOX-LZ

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051910

Encoded Proteins

IDBP-207344

SRY-box containing gene 6

IDBP-268400

SRY-box containing gene 6

IDBP-620254

SRY-box containing gene 6

IDBP-620255

SRY-box containing gene 6

IDBP-620256

SRY-box containing gene 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:115471344-116038744

Strand

Reverse strand

Band

Transcripts

ENSMUST00000072804	ENSMUSP00000072583
ENSMUST00000106612	ENSMUSP00000102223
ENSMUST00000166877	ENSMUSP00000129512
ENSMUST00000169129	ENSMUSP00000126404
ENSMUST00000166207	ENSMUSP00000129027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0016458	gene silencing
GO:0021778	oligodendrocyte cell fate specification
GO:0030097	hemopoiesis
GO:0030218	erythrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0042692	muscle cell differentiation
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048708	astrocyte differentiation
GO:0048709	oligodendrocyte differentiation
GO:0048821	erythrocyte development
GO:0051216	cartilage development
GO:0055007	cardiac muscle cell differentiation
GO:0061036	positive regulation of cartilage development
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000741	positive regulation of mesenchymal stem cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000110693

View Gene Order

ENSBTAG00000044185

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.323365 Mm.471373

RefSeq

NM_001025559 NM_001025560 NM_001277326 NM_001277327 NM_001277328 NM_011445 XM_006507493 XM_006507494 XM_006507495 XM_006507496 XM_006507497 XM_006507498 XM_006507499 XM_006507500 XM_006507501 XM_006507502 XM_006507503 XM_006507504 XM_006507505 XM_006507506 XM_006507507 XM_006507510 XM_006507511 XM_006507512 XM_006507513 XM_006507515

OMIM

CCDS

CCDS40097 CCDS40098 CCDS52369

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas