Version 5.4
Bos taurus Gene: INSC
Summary
InnateDB Gene IDBG-632761.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSC
Gene Name protein inscuteable homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000032782
Encoded Proteins
IDBP-684417
inscuteable homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188487:
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:37874414-38013439
Strand Reverse strand
Band
Transcripts
ENSBTAT00000046553 ENSBTAP00000043841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000188487
View Gene Order
ENSMUSG00000048782
View Gene Order
Cross-References
SwissProt
TrEMBL F1MSC0
UniProt Splice Variant
Entrez Gene 784497
UniGene Bt.85785
RefSeq NM_001205483 XM_005216065
HUGO HGNC:33116
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02040620 DAAA02040621 DAAA02040622
GenPept
RNA Seq Atlas 784497

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca