InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UNC13B

Summary

InnateDB Gene

IDBG-632942.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC13B

Gene Name

protein unc-13 homolog B

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011397

Encoded Proteins

IDBP-684624

unc-13 homolog B (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198722:
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:59797489-60010848

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015153

ENSBTAP00000015153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016082	synaptic vesicle priming
GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0060384	innervation