InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NOTCH4

Summary

InnateDB Gene

IDBG-632984.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOTCH4

Gene Name

neurogenic locus notch homolog protein 4 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000025424

Encoded Proteins

IDBP-684694

notch 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204301:
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:26973191-26998620

Strand

Forward strand

Band

Transcripts

ENSBTAT00000050083

ENSBTAP00000046844

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0030879	mammary gland development
GO:0050793	regulation of developmental process