InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Notch4

Summary

InnateDB Gene

IDBG-171820.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Notch4

Gene Name

notch 4

Synonyms

Int-3; Int3; N4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015468

Encoded Proteins

IDBP-171822

Notch gene homolog 4 (Drosophila)

IDBP-627312

Notch gene homolog 4 (Drosophila)

IDBP-627311

Notch gene homolog 4 (Drosophila)

IDBP-627307

Notch gene homolog 4 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204301:
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34564268-34588503

Strand

Forward strand

Band

Transcripts

ENSMUST00000015612	ENSMUSP00000015612
ENSMUST00000126950
ENSMUST00000152714
ENSMUST00000151867	ENSMUSP00000134497
ENSMUST00000151654	ENSMUSP00000133646
ENSMUST00000128314
ENSMUST00000150441
ENSMUST00000141768
ENSMUST00000126702
ENSMUST00000156724
ENSMUST00000173389	ENSMUSP00000133574
ENSMUST00000174707

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001886	endothelial cell morphogenesis
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0030879	mammary gland development
GO:0045446	endothelial cell differentiation
GO:0050793	regulation of developmental process