InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP2A2

Summary

InnateDB Gene

IDBG-633099.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2A2

Gene Name

sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001398

Encoded Proteins

IDBP-684782

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174437:
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:56458750-56512895

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001838

ENSBTAP00000001838

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016787	hydrolase activity
GO:0019829	cation-transporting ATPase activity
GO:0019899	enzyme binding
GO:0044548	S100 protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006984	ER-nucleus signaling pathway
GO:0008152	metabolic process
GO:0045822	negative regulation of heart contraction
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum