InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANO6

Summary

InnateDB Gene

IDBG-633238.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANO6

Gene Name

Uncharacterized protein

Synonyms

TMEM16F

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002902

Encoded Proteins

IDBP-684974

anoctamin 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25651887

[Homo sapiens] Stimulation of P2RX7 receptors activates ANO6 to enhance bacterial phagocytosis and killing by macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177119:
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:35059697-35150452

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003770

ENSBTAP00000003770

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005227	calcium activated cation channel activity
GO:0005229	intracellular calcium activated chloride channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0017128	phospholipid scramblase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0002543	activation of blood coagulation via clotting cascade
GO:0006812	cation transport
GO:0006821	chloride transport
GO:0007596	blood coagulation
GO:0017121	phospholipid scrambling
GO:0035630	bone mineralization involved in bone maturation
GO:0044070	regulation of anion transport
GO:0061588	calcium activated phospholipid scrambling
GO:0061589	calcium activated phosphatidylserine scrambling
GO:0061590	calcium activated phosphatidylcholine scrambling
GO:0061591	calcium activated galactosylceramide scrambling
GO:0097045	phosphatidylserine exposure on blood platelet
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0034707	chloride channel complex
GO:0070062	extracellular vesicular exosome