InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDIA3

Summary

InnateDB Gene

IDBG-633244.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDIA3

Gene Name

protein disulfide-isomerase A3 precursor

Synonyms

GRP58

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017196

Encoded Proteins

IDBP-684952

protein disulfide-isomerase A3 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167004:
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:55924230-55946434

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022854

ENSBTAP00000022854

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006457	protein folding
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway