Version 5.4
Bos taurus Gene: PDE1C
Summary
InnateDB Gene IDBG-633326.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE1C
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002739
Encoded Proteins
IDBP-685048
phosphodiesterase 1C, calmodulin-dependent 70kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154678:
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:64985737-65050206
Strand Forward strand
Band
Transcripts
ENSBTAT00000003553 ENSBTAP00000003553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0007608 sensory perception of smell
GO:0008152 metabolic process
Cellular Component
GO:0005929 cilium
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000154678
View Gene Order
ENSMUSG00000004347
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15408
Cam-PDE 1 activation pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_15307
Ca-dependent events pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_188190
PLCG1 events in ERBB2 signaling pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_259326
Ca-dependent events pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_230745
Immune System pathway
REACT_236516
EGFR interacts with phospholipase C-gamma pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_240702
CaM pathway pathway
REACT_242976
Signaling by EGFR pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_227001
Cam-PDE 1 activation pathway
REACT_248921
Signalling by NGF pathway
REACT_263353
Signaling by PDGF pathway
REACT_188269
DAG and IP3 signaling pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242845
Opioid Signalling pathway
REACT_215587
Calmodulin induced events pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_253342
PLC beta mediated events pathway
REACT_248370
G-protein mediated events pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04740
Olfactory transduction pathway
hsa00230
Purine metabolism pathway
hsa04020
Calcium signaling pathway pathway
mmu04740
Olfactory transduction pathway
mmu04020
Calcium signaling pathway pathway
mmu00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MCY0
UniProt Splice Variant
Entrez Gene 526211
UniGene Bt.110897
RefSeq XM_002686835 XM_005198067 XM_005198068 XM_005198069 XM_005205483 XM_005205484 XM_604573
HUGO HGNC:8776
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02010881
GenPept
RNA Seq Atlas 526211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca