InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ENSA

Summary

InnateDB Gene

IDBG-633348.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENSA

Gene Name

Alpha-endosulfine

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007123

Encoded Proteins

IDBP-685046

alpha-endosulfine

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143420:
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:20141694-20146997

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009379

ENSBTAP00000009379

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0005102	receptor binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0019212	phosphatase inhibitor activity
GO:0019870	potassium channel inhibitor activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0043086	negative regulation of catalytic activity
GO:0050790	regulation of catalytic activity
GO:0050796	regulation of insulin secretion
GO:0051301	cell division