Bos taurus Gene: HRK
Summary
InnateDB Gene IDBG-633660.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRK
Gene Name activator of apoptosis harakiri
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000047484
Encoded Proteins
harakiri, BCL2 interacting protein (contains only BH3 domain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135116:
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:60417162-60437117
Strand Forward strand
Band
Transcripts
ENSBTAT00000064996 ENSBTAP00000053969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0032464 positive regulation of protein homooligomerization
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ATF-2 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.88186
RefSeq NM_001191241
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas