Mus musculus Gene: Hrk
Summary
InnateDB Gene IDBG-195140.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hrk
Gene Name harakiri, BCL2 interacting protein (contains only BH3 domain)
Synonyms AI838259; Bid3; DP5; harakiri
Species Mus musculus
Ensembl Gene ENSMUSG00000046607
Encoded Proteins
harakiri, BCL2 interacting protein (contains only BH3 domain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135116:
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:118164648-118189478
Strand Forward strand
Band F
Transcripts
ENSMUST00000054836 ENSMUSP00000057532
ENSMUST00000184679
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0032464 positive regulation of protein homooligomerization
GO:0043065 positive regulation of apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ATF-2 transcription factor network
Cross-References
SwissProt P62816
TrEMBL
UniProt Splice Variant
Entrez Gene 12123
UniGene Mm.138979 Mm.384468 Mm.396955 Mm.428588
RefSeq NM_007545
OMIM
CCDS CCDS39236
HPRD
IMGT
MGI ID MGI:1201608
MGI Symbol Hrk
EMBL D83698
GenPept BAA12066
RNA Seq Atlas 12123