Version 5.4
Bos taurus Gene: GGT6
Summary
InnateDB Gene IDBG-633667.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGT6
Gene Name Gamma-glutamyltransferase 6 Gamma-glutamyltransferase 6 heavy chain Gamma-glutamyltransferase 6 light chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007436
Encoded Proteins
IDBP-685387
Gamma-glutamyltransferase 6Gamma-glutamyltransferase 6 heavy chainGamma-glutamyltransferase 6 light chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167741:
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:25652195-25655086
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035110 ENSBTAP00000034988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016787 hydrolase activity
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000167741
View Gene Order
ENSMUSG00000040471
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00460
Cyanoamino acid metabolism pathway
hsa00430
Taurine and hypotaurine metabolism pathway
hsa00480
Glutathione metabolism pathway
mmu00480
Glutathione metabolism pathway
mmu00430
Taurine and hypotaurine metabolism pathway
mmu00460
Cyanoamino acid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt A7YWM1
TrEMBL
UniProt Splice Variant
Entrez Gene 613919
UniGene Bt.27489
RefSeq NM_001105434
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134652
GenPept AAI34653
RNA Seq Atlas 613919

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca