Version 5.4
Homo sapiens Gene: GGT6
Summary
InnateDB Gene IDBG-18985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGT6
Gene Name gamma-glutamyltransferase 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167741
Encoded Proteins
IDBP-18987
gamma-glutamyltransferase 6
IDBP-18989
gamma-glutamyltransferase 6
IDBP-759768
IDBP-759567
IDBP-758193
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4556927-4560818
Strand Reverse strand
Band p13.2
Transcripts
ENST00000301395 ENSP00000301395
ENST00000381550 ENSP00000370962
ENST00000575573
ENST00000573591 ENSP00000461230
ENST00000574154 ENSP00000458307
ENST00000574584 ENSP00000459662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
GO:0036374 glutathione hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0019370 leukotriene biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040471
View Gene Order
ENSBTAG00000007436
Not yet available
Pathways
NETPATH
REACTOME
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00460
Cyanoamino acid metabolism pathway
hsa00430
Taurine and hypotaurine metabolism pathway
hsa00480
Glutathione metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B4DPG6
UniProt Splice Variant
Entrez Gene 124975
UniGene Hs.130749 Hs.606318
RefSeq NM_001122890 NM_001288702 NM_001288703 NM_001288704 NM_153338
HUGO HGNC:26891
OMIM 612341
CCDS CCDS11047 CCDS45582 CCDS73942
HPRD 08293
IMGT
EMBL AC118754 AK298329
GenPept BAG60578
RNA Seq Atlas 124975

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca