Version 5.4
Bos taurus Gene: PDZK1
Summary
InnateDB Gene IDBG-633736.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDZK1
Gene Name Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005810
Encoded Proteins
IDBP-685468
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174827:
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:21755127-21801218
Strand Forward strand
Band
Transcripts
ENSBTAT00000007638 ENSBTAP00000007638
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0006810 transport
GO:0015879 carnitine transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0090002 establishment of protein localization to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000174827
View Gene Order
ENSMUSG00000038298
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3T0X8
TrEMBL
UniProt Splice Variant
Entrez Gene 534439
UniGene Bt.45257
RefSeq NM_001034611 XM_005203989 XM_005203990
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102213
GenPept AAI02214
RNA Seq Atlas 534439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca