Version 5.4
Bos taurus Gene: ICMT
Summary
InnateDB Gene IDBG-633892.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICMT
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000048308
Encoded Proteins
IDBP-685642
isoprenylcysteine carboxyl methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116237:
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:47960246-47967797
Strand Reverse strand
Band
Transcripts
ENSBTAT00000064297 ENSBTAP00000055858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0008140 cAMP response element binding protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0006479 protein methylation
GO:0006481 C-terminal protein methylation
GO:0008104 protein localization
GO:0008284 positive regulation of cell proliferation
GO:0035264 multicellular organism growth
GO:0046578 regulation of Ras protein signal transduction
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000116237
View Gene Order
ENSMUSG00000039662
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
mmu00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3N1V4
UniProt Splice Variant
Entrez Gene 785548
UniGene
RefSeq
HUGO HGNC:5350
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043088 DAAA02043089
GenPept
RNA Seq Atlas 785548
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca