Version 5.4
Mus musculus Gene: Icmt
Summary
InnateDB Gene IDBG-206599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Icmt
Gene Name isoprenylcysteine carboxyl methyltransferase
Synonyms 1700008E11Rik; C80758; Gm13095; HSTE14; OTTMUSG00000010406; pcCMT; PPMT; STE14
Species Mus musculus
Ensembl Gene ENSMUSG00000039662
Encoded Proteins
IDBP-206601
isoprenylcysteine carboxyl methyltransferase
IDBP-624444
isoprenylcysteine carboxyl methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116237:
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:152297227-152307121
Strand Forward strand
Band E2
Transcripts
ENSMUST00000048892 ENSMUSP00000043390
ENSMUST00000134242
ENSMUST00000151372 ENSMUSP00000133950
ENSMUST00000125617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0008140 cAMP response element binding protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0006479 protein methylation
GO:0006481 C-terminal protein methylation
GO:0008104 protein localization
GO:0008284 positive regulation of cell proliferation
GO:0035264 multicellular organism growth
GO:0046578 regulation of Ras protein signal transduction
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116237
View Gene Order
ENSBTAG00000048308
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.277464 Mm.475570
RefSeq NM_133788
OMIM
CCDS CCDS18998
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca