InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPTBN1

Summary

InnateDB Gene

IDBG-633932.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTBN1

Gene Name

spectrin beta chain, brain 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006995

Encoded Proteins

IDBP-685674

spectrin, beta, non-erythrocytic 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115306:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:37030009-37241384

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009208

ENSBTAP00000009208

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030506	ankyrin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007009	plasma membrane organization
GO:0043001	Golgi to plasma membrane protein transport
GO:0071709	membrane assembly
GO:0072661	protein targeting to plasma membrane