InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DLG1

Summary

InnateDB Gene

IDBG-634119.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020378

Encoded Proteins

IDBP-685919

discs, large homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075711:
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:72122240-72297319

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027161

ENSBTAP00000027161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0032947	protein complex scaffold
GO:0044325	ion channel binding
GO:0097016	L27 domain binding

Biological Process

GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001771	immunological synapse formation
GO:0001935	endothelial cell proliferation
GO:0002088	lens development in camera-type eye
GO:0002369	T cell cytokine production
GO:0007015	actin filament organization
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030432	peristalsis
GO:0030838	positive regulation of actin filament polymerization
GO:0030866	cortical actin cytoskeleton organization
GO:0031579	membrane raft organization
GO:0031641	regulation of myelination
GO:0032147	activation of protein kinase activity
GO:0042110	T cell activation
GO:0042130	negative regulation of T cell proliferation
GO:0042391	regulation of membrane potential
GO:0042982	amyloid precursor protein metabolic process
GO:0043268	positive regulation of potassium ion transport
GO:0045930	negative regulation of mitotic cell cycle
GO:0048608	reproductive structure development
GO:0048704	embryonic skeletal system morphogenesis
GO:0048729	tissue morphogenesis
GO:0048745	smooth muscle tissue development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051898	negative regulation of protein kinase B signaling
GO:0060022	hard palate development
GO:0070830	tight junction assembly
GO:0072659	protein localization to plasma membrane
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0001772	immunological synapse
GO:0005605	basal lamina
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0009898	cytoplasmic side of plasma membrane
GO:0014069	postsynaptic density
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0031253	cell projection membrane
GO:0031594	neuromuscular junction
GO:0033268	node of Ranvier
GO:0035748	myelin sheath abaxonal region
GO:0043219	lateral loop
GO:0045121	membrane raft
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097025	MPP7-DLG1-LIN7 complex