InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FANCL

Summary

InnateDB Gene

IDBG-634255.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FANCL

Gene Name

E3 ubiquitin-protein ligase FANCL

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005870

Encoded Proteins

IDBP-686030

E3 ubiquitin-protein ligase FANCL

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115392:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:40656144-40744419

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007713

ENSBTAP00000007713

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006513	protein monoubiquitination
GO:0006974	cellular response to DNA damage stimulus
GO:0007276	gamete generation
GO:0042127	regulation of cell proliferation