Version 5.4
Bos taurus Gene: GP5
Summary
InnateDB Gene IDBG-634289.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GP5
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013203
Encoded Proteins
IDBP-686056
glycoprotein V (platelet)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178732:
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:73740503-73776574
Strand Forward strand
Band
Transcripts
ENSBTAT00000017571 ENSBTAP00000017571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0010544 negative regulation of platelet activation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000178732
View Gene Order
ENSMUSG00000047953
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_326
Intrinsic Pathway pathway
REACT_23847
GP1b-IX-V activation signalling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04512
ECM-receptor interaction pathway
mmu04512
ECM-receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_005196107 XM_005201559
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca