Version 5.4
Bos taurus Gene: TRAFD1
Summary
InnateDB Gene IDBG-634307.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAFD1
Gene Name TRAF-type zinc finger domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008761
Encoded Proteins
IDBP-686099
TRAF-type zinc finger domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18849341
[Homo sapiens] TRAFD1 deficiency reveals its negative regulatory role in the TLR and RIG-I-like helicases signalling pathway and was found to interact with TRIF, IPS-1, TRAF3 and TRAF6 in mice
PMID 16221674
[Homo sapiens] TRAFD1 is an interferon and LPS inducible gene acting as a negative regulator of Toll-like receptor signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135148:
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64313879-64328239
Strand Reverse strand
Band
Transcripts
ENSBTAT00000011542 ENSBTAP00000011542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045824 negative regulation of innate immune response
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135148
View Gene Order
ENSMUSG00000042726
View Gene Order
Cross-References
SwissProt
TrEMBL E1BDP8
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:24808
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045436 DAAA02045437
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca