Version 5.4
Homo sapiens Gene: IFT80
Summary
InnateDB Gene IDBG-63437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFT80
Gene Name intraflagellar transport 80 homolog (Chlamydomonas)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000068885
Encoded Proteins
IDBP-63441
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-484167
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-483712
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-474698
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-481941
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-476900
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-475553
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-474843
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-473371
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-483226
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-480777
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-475580
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-474580
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-477007
intraflagellar transport 80 homolog (Chlamydomonas)
IDBP-482824
intraflagellar transport 80 homolog (Chlamydomonas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of the intraflagellar transport complex B and is necessary for the function of motile and sensory cilia. Defects in this gene are a cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:160256986-160399880
Strand Reverse strand
Band q25.33
Transcripts
ENST00000326448 ENSP00000312778
ENST00000483465 ENSP00000418196
ENST00000496589 ENSP00000420646
ENST00000487943
ENST00000478278
ENST00000463240
ENST00000483325 ENSP00000417552
ENST00000472555 ENSP00000420401
ENST00000461213
ENST00000478460
ENST00000465537 ENSP00000418602
ENST00000484963 ENSP00000420260
ENST00000475677 ENSP00000419458
ENST00000472773
ENST00000498409 ENSP00000420001
ENST00000468218 ENSP00000417057
ENST00000478370 ENSP00000420758
ENST00000486856 ENSP00000417861
ENST00000477495
ENST00000482317 ENSP00000418497
ENST00000489004 ENSP00000418455
ENST00000465972
ENST00000468327
ENST00000478536 ENSP00000419468
ENST00000498145
ENST00000467254
ENST00000466326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0002062 chondrocyte differentiation
GO:0007224 smoothened signaling pathway
GO:0042384 cilium assembly
GO:0045880 positive regulation of smoothened signaling pathway
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060271 cilium morphogenesis
GO:0060349 bone morphogenesis
GO:2000051 negative regulation of non-canonical Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005929 cilium
GO:0030992 intraciliary transport particle B
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027778
View Gene Order
ENSBTAG00000031572
Not yet available
Cross-References
SwissProt Q9P2H3
TrEMBL C9IZR2 C9J6G8 C9J6I5 C9JUJ1
UniProt Splice Variant
Entrez Gene 57560
UniGene Hs.478095 Hs.679737 Hs.704068
RefSeq NM_001190242 NM_001190241 NM_020800
HUGO HGNC:29262
OMIM 611177
CCDS CCDS54668 CCDS3188
HPRD 13853
IMGT
EMBL AB037795 AC024221 AC079594 AK303410 AL133045 BC030774 BC042027 BC101494 BC113669 CH471052
GenPept AAH42027 AAI01495 AAI13670 BAA92612 BAG64463 CAB61372 EAW78643 EAW78644 EAW78645 EAW78646 EAW78648
RNA Seq Atlas 57560

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca