InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MGC142792

Summary

InnateDB Gene

IDBG-634405.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGC142792

Gene Name

LIM and senescent cell antigen-like-containing domain protein 1

Synonyms

LIMS3; LIMS3L

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010971

Encoded Proteins

IDBP-686180

hypothetical protein LOC540281

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169756:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:44577636-44658623

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014566

ENSBTAP00000014566

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0016337	single organismal cell-cell adhesion
GO:0043009	chordate embryonic development
GO:0043066	negative regulation of apoptotic process
GO:0045216	cell-cell junction organization
GO:0050680	negative regulation of epithelial cell proliferation
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000346	negative regulation of hepatocyte proliferation
GO:2001046	positive regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005925

focal adhesion

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000169756

View Gene Order

ENSMUSG00000019920

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20580

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway

REACT_20649

Cell-extracellular matrix interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

KEGG

INOH

PID NCI

ilk_pathway

Integrin-linked kinase signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.104115

RefSeq

NM_001083495 XM_005212660 XM_005212661 XM_005212662

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas