Version 5.4
| Bos taurus Gene: IL1RAP | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-634437.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | IL1RAP | ||||||||
| Gene Name | interleukin-1 receptor accessory protein precursor | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000013205 | ||||||||
| Encoded Proteins |
interleukin 1 receptor accessory protein
interleukin 1 receptor accessory protein
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] IL1RAP is recruited to the IL1B::IL1R1 ligand-receptor complex to initiate the IL1B signalling cascade.
[Mus musculus] Il1rap is recruited to the Il1b::Il1r1 ligand-receptor complex to initiate the Il1b signalling cascade. (Demonstrated in human)
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196083:
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 1:77198182-77343645 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
IL1 pathway
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| REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
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| KEGG |
Apoptosis pathway
Cytokine-cytokine receptor interaction pathway
Cytokine-cytokine receptor interaction pathway
Apoptosis pathway
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| INOH |
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
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| PID NCI |
IL1-mediated signaling events
p73 transcription factor network
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | E1BFL8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 539334 | ||||||||
| UniGene | Bt.108111 Bt.28708 | ||||||||
| RefSeq | XM_005201515 NM_001076155 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02001792 DAAA02001793 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 539334 | ||||||||