Version 5.4
Bos taurus Gene: LZTS1
Summary
InnateDB Gene IDBG-634440.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LZTS1
Gene Name leucine zipper putative tumor suppressor 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000841
Encoded Proteins
IDBP-686222
leucine zipper, putative tumor suppressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061337:
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67861051-67867745
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001114 ENSBTAP00000001114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016242 negative regulation of macroautophagy
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000061337
View Gene Order
ENSMUSG00000036306
View Gene Order
Cross-References
SwissProt
TrEMBL E1BHA0
UniProt Splice Variant
Entrez Gene 539634
UniGene Bt.105349
RefSeq NM_001192287
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02023364
GenPept
RNA Seq Atlas 539634

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca