InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GRK1

Summary

InnateDB Gene

IDBG-634554.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK1

Gene Name

Rhodopsin kinase

Synonyms

RHOK

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019963

Encoded Proteins

IDBP-686339

Rhodopsin kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185974:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:90769074-90783057

Strand

Forward strand

Band

Transcripts

ENSBTAT00000045068

ENSBTAP00000042484

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050254	rhodopsin kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007601	visual perception
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008594	photoreceptor cell morphogenesis
GO:0009416	response to light stimulus
GO:0016310	phosphorylation
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0050896	response to stimulus
GO:0060060	post-embryonic retina morphogenesis in camera-type eye