Version 5.4
Bos taurus Gene: EIF4A2
Summary
InnateDB Gene IDBG-634648.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4A2
Gene Name Eukaryotic initiation factor 4A-II
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014724
Encoded Proteins
IDBP-686425
Eukaryotic initiation factor 4A-II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156976:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA81, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:81057779-81064090
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019596 ENSBTAP00000019596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000156976
View Gene Order
ENSMUSG00000022884
View Gene Order
Pathways
NETPATH
REACTOME
REACT_224454
Deadenylation of mRNA pathway
REACT_215264
ISG15 antiviral mechanism pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_213138
Immune System pathway
REACT_224319
Antiviral mechanism by IFN-stimulated genes pathway
REACT_209048
Translation pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_225103
Interferon Signaling pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_224343
Translation initiation complex formation pathway
REACT_203426
Deadenylation-dependent mRNA decay pathway
REACT_222420
Ribosomal scanning and start codon recognition pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_1014
Translation pathway
REACT_25229
Interferon Signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_244119
Deadenylation of mRNA pathway
REACT_254308
Translation pathway
REACT_198535
Antiviral mechanism by IFN-stimulated genes pathway
REACT_198533
ISG15 antiviral mechanism pathway
REACT_230745
Immune System pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_198666
Interferon Signaling pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
Insulin receptor signaling pathway
PID NCI
Cross-References
SwissProt Q3SZ65
TrEMBL Q9XT93
UniProt Splice Variant
Entrez Gene 286819
UniGene Bt.13925
RefSeq NM_001034044 XM_005201461 XM_005201462
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF058806 BC103106
GenPept AAD39339 AAI03107
RNA Seq Atlas 286819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca