InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF4A2

Summary

InnateDB Gene

IDBG-69090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4A2

Gene Name

eukaryotic translation initiation factor 4A2

Synonyms

BM-010; DDX2B; E3; E3-2; eIF-4A-II; EIF4A; eIF4A-II; EIF4F; RNE3; RNU107

Species

Homo sapiens

Ensembl Gene

ENSG00000156976

Encoded Proteins

IDBP-69092

eukaryotic translation initiation factor 4A2

IDBP-386430

eukaryotic translation initiation factor 4A2

IDBP-386432

eukaryotic translation initiation factor 4A2

IDBP-386433

eukaryotic translation initiation factor 4A2

IDBP-386436

eukaryotic translation initiation factor 4A2

IDBP-386437

eukaryotic translation initiation factor 4A2

IDBP-386438

eukaryotic translation initiation factor 4A2

IDBP-386439

eukaryotic translation initiation factor 4A2

IDBP-719680

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA81, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:186783205-186789900

Strand

Forward strand

Band

q27.3

Transcripts

ENST00000323963	ENSP00000326381
ENST00000441007	ENSP00000407504
ENST00000445596	ENSP00000415878
ENST00000426808	ENSP00000392686
ENST00000440191	ENSP00000398370
ENST00000425053	ENSP00000413529
ENST00000429589	ENSP00000388237
ENST00000443963	ENSP00000402313
ENST00000465222
ENST00000491473
ENST00000486805
ENST00000465032
ENST00000465267
ENST00000495049
ENST00000485101
ENST00000475653
ENST00000498746	ENSP00000462571
ENST00000467585
ENST00000466362
ENST00000468362
ENST00000492144
ENST00000465792
ENST00000475409
ENST00000497177
ENST00000494445
ENST00000461021
ENST00000496382

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003743	translation initiation factor activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006200	ATP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0044267	cellular protein metabolic process