InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: OPRM1

Summary

InnateDB Gene

IDBG-635007.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OPRM1

Gene Name

mu-type opioid receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019719

Encoded Proteins

IDBP-686807

mu-type opioid receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112038:
This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:92152082-92209694

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026280

ENSBTAP00000026280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004979	beta-endorphin receptor activity
GO:0004985	opioid receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007626	locomotory behavior
GO:0019233	sensory perception of pain
GO:0033554	cellular response to stress
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0048149	behavioral response to ethanol
GO:0050769	positive regulation of neurogenesis
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0061358	negative regulation of Wnt protein secretion