InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Oprm1

Summary

InnateDB Gene

IDBG-130147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oprm1

Gene Name

opioid receptor, mu 1

Synonyms

M-OR-1; MOP-R; mor; MOR-1; MOR-1O; muOR; Oprm

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000766

Encoded Proteins

IDBP-130149

opioid receptor, mu 1

IDBP-130151

opioid receptor, mu 1

IDBP-130153

opioid receptor, mu 1

IDBP-130155

opioid receptor, mu 1

IDBP-130157

opioid receptor, mu 1

IDBP-130159

opioid receptor, mu 1

IDBP-130161

opioid receptor, mu 1

IDBP-130167

opioid receptor, mu 1

IDBP-270497

opioid receptor, mu 1

IDBP-270501

opioid receptor, mu 1

IDBP-270505

opioid receptor, mu 1

IDBP-270507

opioid receptor, mu 1

IDBP-270509

opioid receptor, mu 1

IDBP-270511

opioid receptor, mu 1

IDBP-270513

opioid receptor, mu 1

IDBP-270515

opioid receptor, mu 1

IDBP-270517

opioid receptor, mu 1

IDBP-539876

opioid receptor, mu 1

IDBP-531774

opioid receptor, mu 1

IDBP-534421

opioid receptor, mu 1

IDBP-538357

opioid receptor, mu 1

IDBP-535682

opioid receptor, mu 1

IDBP-714339

IDBP-534323

opioid receptor, mu 1

IDBP-537788

opioid receptor, mu 1

IDBP-538106

opioid receptor, mu 1

IDBP-537383

opioid receptor, mu 1

IDBP-541680

opioid receptor, mu 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Alternatively spliced transcript variants have been found for this gene, however, many of these variants may be NMD candidates. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:6758506-7038198

Strand

Forward strand

Band

Transcripts

ENSMUST00000063036	ENSMUSP00000053498
ENSMUST00000052751	ENSMUSP00000060329
ENSMUST00000092731	ENSMUSP00000090407
ENSMUST00000056385	ENSMUSP00000060590
ENSMUST00000092729	ENSMUSP00000090405
ENSMUST00000000783	ENSMUSP00000000783
ENSMUST00000078634	ENSMUSP00000077704
ENSMUST00000092734	ENSMUSP00000090410
ENSMUST00000105615	ENSMUSP00000101240
ENSMUST00000105611	ENSMUSP00000101236
ENSMUST00000105607	ENSMUSP00000101232
ENSMUST00000105605	ENSMUSP00000101230
ENSMUST00000105604	ENSMUSP00000101229
ENSMUST00000105603	ENSMUSP00000101228
ENSMUST00000105602	ENSMUSP00000101227
ENSMUST00000105601	ENSMUSP00000101226
ENSMUST00000105597	ENSMUSP00000101222
ENSMUST00000141897
ENSMUST00000144264	ENSMUSP00000115836
ENSMUST00000129221	ENSMUSP00000123117
ENSMUST00000154941	ENSMUSP00000115413
ENSMUST00000129954	ENSMUSP00000122385
ENSMUST00000123861	ENSMUSP00000120187
ENSMUST00000135502	ENSMUSP00000135143
ENSMUST00000147171	ENSMUSP00000117950
ENSMUST00000152674	ENSMUSP00000115552
ENSMUST00000148625
ENSMUST00000150374	ENSMUSP00000114856
ENSMUST00000154906	ENSMUSP00000114342
ENSMUST00000143875	ENSMUSP00000123617
ENSMUST00000133486

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0004979	beta-endorphin receptor activity
GO:0004985	opioid receptor activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0031005	filamin binding
GO:0031681	G-protein beta-subunit binding
GO:0038047	morphine receptor activity

Biological Process

GO:0002438	acute inflammatory response to antigenic stimulus
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007626	locomotory behavior
GO:0019233	sensory perception of pain
GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway
GO:0032094	response to food
GO:0032100	positive regulation of appetite
GO:0032496	response to lipopolysaccharide
GO:0033554	cellular response to stress
GO:0038003	opioid receptor signaling pathway
GO:0042060	wound healing
GO:0042220	response to cocaine
GO:0043278	response to morphine
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0048149	behavioral response to ethanol
GO:0050769	positive regulation of neurogenesis
GO:0050795	regulation of behavior
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0051930	regulation of sensory perception of pain
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0061358	negative regulation of Wnt protein secretion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070588	calcium ion transmembrane transport
GO:0070848	response to growth factor
GO:0071315	cellular response to morphine
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0032590	dendrite membrane
GO:0032839	dendrite cytoplasm
GO:0042383	sarcolemma
GO:0043204	perikaryon
GO:0045121	membrane raft