InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: THPO

Summary

InnateDB Gene

IDBG-635050.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THPO

Gene Name

thrombopoietin precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000476

Encoded Proteins

IDBP-686849

thrombopoietin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090534:
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012]
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5\' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:83429600-83434371

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000602

ENSBTAP00000000602

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0008283	cell proliferation
GO:0030099	myeloid cell differentiation
GO:0038163	thrombopoietin-mediated signaling pathway
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade