Version 5.4
Bos taurus Gene: SUCLG1
Summary
InnateDB Gene IDBG-635278.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUCLG1
Gene Name succinyl-CoA ligase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006075
Encoded Proteins
IDBP-687108
succinyl-CoA ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163541:
This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:50400445-50453412
Strand Forward strand
Band
Transcripts
ENSBTAT00000007982 ENSBTAP00000007982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003878 ATP citrate synthase activity
GO:0004775 succinate-CoA ligase (ADP-forming) activity
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
GO:0048037 cofactor binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163541
View Gene Order
ENSMUSG00000052738
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_249033
Citric acid cycle (TCA cycle) pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00640
Propanoate metabolism pathway
mmu00020
Citrate cycle (TCA cycle) pathway
mmu00640
Propanoate metabolism pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MZ38
UniProt Splice Variant
Entrez Gene 509983
UniGene
RefSeq NM_001035082
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031168 DAAA02031169 DAAA02031170
GenPept
RNA Seq Atlas 509983

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca