Version 5.4
Bos taurus Gene: BT.70166
Summary
InnateDB Gene IDBG-635279.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.70166
Gene Name endothelin-converting enzyme 2 isoform 2b-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005658
Encoded Proteins
IDBP-687182
endothelin-converting enzyme 2 isoform 2b-2
IDBP-687186
endothelin-converting enzyme 2 isoform 2b-2
IDBP-687190
endothelin-converting enzyme 2 isoform 2b-2
IDBP-687192
endothelin-converting enzyme 2 isoform 2b-2
IDBP-687197
endothelin-converting enzyme 2 isoform 2b-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145194:
Endothelin-converting enzymes, such as ECE2 (EC 3.4.24.71), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001 [PubMed 11718899]).[supplied by OMIM, Mar 2008]
This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:83507399-83539930
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045385 ENSBTAP00000042778
ENSBTAT00000007428 ENSBTAP00000007428
ENSBTAT00000007435 ENSBTAP00000007435
ENSBTAT00000064205 ENSBTAP00000053896
ENSBTAT00000064633 ENSBTAP00000055807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008168 methyltransferase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
GO:0016486 peptide hormone processing
GO:0032259 methylation
Cellular Component
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145194
View Gene Order
ENSMUSG00000022842
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4840 Bt.70166
RefSeq NM_174046 NM_177956 NM_177957 NM_177958 XM_005201577
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca