Version 5.4
Bos taurus Gene: BT.58045
Summary
InnateDB Gene IDBG-635435.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.58045
Gene Name COMM domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019867
Encoded Proteins
IDBP-687269
COMM domain-containing protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173163:
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60427663-60598437
Strand Forward strand
Band
Transcripts
ENSBTAT00000026470 ENSBTAP00000026470
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0031398 positive regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0055070 copper ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000173163
View Gene Order
ENSMUSG00000051355
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N3M7
UniProt Splice Variant
Entrez Gene 534683
UniGene Bt.58045
RefSeq NM_001046384
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031383 DAAA02031384 DAAA02031385 DAAA02031386
GenPept
RNA Seq Atlas 534683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca