InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DAO

Summary

InnateDB Gene

IDBG-635477.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAO

Gene Name

D-amino-acid oxidase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018831

Encoded Proteins

IDBP-687338

D-amino-acid oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110887:
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:66356385-66369068

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025068

ENSBTAP00000025068

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003884	D-amino-acid oxidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0046983	protein dimerization activity
GO:0048037	cofactor binding
GO:0071949	FAD binding

Biological Process

GO:0006551	leucine metabolic process
GO:0006562	proline catabolic process
GO:0036088	D-serine catabolic process
GO:0042416	dopamine biosynthetic process
GO:0055114	oxidation-reduction process
GO:0055130	D-alanine catabolic process
GO:0070178	D-serine metabolic process