Version 5.4
Bos taurus Gene: UGP2
Summary
InnateDB Gene IDBG-635514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UGP2
Gene Name UTP--glucose-1-phosphate uridylyltransferase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000111
Encoded Proteins
IDBP-687358
UTP--glucose-1-phosphate uridylyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169764:
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62244354-62299938
Strand Forward strand
Band
Transcripts
ENSBTAT00000044762 ENSBTAP00000042228
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0070569 uridylyltransferase activity
Biological Process
GO:0006011 UDP-glucose metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169764
View Gene Order
ENSMUSG00000001891
View Gene Order
Pathways
NETPATH
REACTOME
REACT_213093
Glycogen synthesis pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_214113
Formation of the active cofactor, UDP-glucuronate pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_218176
Biological oxidations pathway
REACT_211129
Glycogen storage diseases pathway
REACT_224672
Glucose metabolism pathway
REACT_219139
Metabolism pathway
REACT_213008
Phase II conjugation pathway
REACT_207087
Disease pathway
REACT_204452
Glucuronidation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6737
Formation of the active cofactor, UDP-glucuronate pathway
REACT_6784
Glucuronidation pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_169208
Glycogen synthesis pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_189085
Disease pathway
REACT_243247
Phase II conjugation pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_188939
Glycogen synthesis pathway
REACT_230621
Formation of the active cofactor, UDP-glucuronate pathway
REACT_257519
Glucuronidation pathway
REACT_203949
Glycogen storage diseases pathway
REACT_232343
Biological oxidations pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu00500
Starch and sucrose metabolism pathway
mmu00040
Pentose and glucuronate interconversions pathway
mmu00052
Galactose metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Galactose metabolism pathway
PID NCI
Cross-References
SwissProt Q07130
TrEMBL
UniProt Splice Variant
Entrez Gene 281565
UniGene Bt.3567
RefSeq NM_174212 XM_005212739
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118181 L14019
GenPept AAA30801 AAI18182
RNA Seq Atlas 281565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca