Version 5.4
Mus musculus Gene: Ugp2
Summary
InnateDB Gene IDBG-153407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ugp2
Gene Name UDP-glucose pyrophosphorylase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000001891
Encoded Proteins
IDBP-153409
UDP-glucose pyrophosphorylase 2
IDBP-153411
UDP-glucose pyrophosphorylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169764:
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:21321138-21371201
Strand Reverse strand
Band A3.1
Transcripts
ENSMUST00000102875 ENSMUSP00000099939
ENSMUST00000060895 ENSMUSP00000056324
ENSMUST00000133343
ENSMUST00000143890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
GO:0005515 protein binding
GO:0005536 glucose binding
GO:0016779 nucleotidyltransferase activity
GO:0032557 pyrimidine ribonucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006011 UDP-glucose metabolic process
GO:0008152 metabolic process
GO:0019255 glucose 1-phosphate metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169764
View Gene Order
ENSBTAG00000000111
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_243247
Phase II conjugation pathway
REACT_261601
Glucose metabolism pathway
REACT_188937
Metabolism pathway
REACT_188939
Glycogen synthesis pathway
REACT_230621
Formation of the active cofactor, UDP-glucuronate pathway
REACT_257519
Glucuronidation pathway
REACT_203949
Glycogen storage diseases pathway
REACT_232343
Biological oxidations pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu00500
Starch and sucrose metabolism pathway
mmu00040
Pentose and glucuronate interconversions pathway
mmu00052
Galactose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6737
Formation of the active cofactor, UDP-glucuronate pathway
REACT_6784
Glucuronidation pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_169208
Glycogen synthesis pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_213093
Glycogen synthesis pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_214113
Formation of the active cofactor, UDP-glucuronate pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_218176
Biological oxidations pathway
REACT_211129
Glycogen storage diseases pathway
REACT_224672
Glucose metabolism pathway
REACT_219139
Metabolism pathway
REACT_213008
Phase II conjugation pathway
REACT_207087
Disease pathway
REACT_204452
Glucuronidation pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00500
Starch and sucrose metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Galactose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28877
RefSeq NM_001290634 NM_139297 XM_006514630
OMIM
CCDS CCDS24464 CCDS70148
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca