Version 5.4
Bos taurus Gene: PARL
Summary
InnateDB Gene IDBG-635546.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARL
Gene Name Presenilins-associated rhomboid-like protein, mitochondrial P-beta
Synonyms PSARL
Species Bos taurus
Ensembl Gene ENSBTAG00000014460
Encoded Proteins
IDBP-687390
Presenilins-associated rhomboid-like protein, mitochondrialP-beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175193:
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:83860274-83914710
Strand Forward strand
Band
Transcripts
ENSBTAT00000019227 ENSBTAP00000019227
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000175193
View Gene Order
ENSMUSG00000033918
View Gene Order
Cross-References
SwissProt Q2KHV4
TrEMBL
UniProt Splice Variant
Entrez Gene 514191
UniGene Bt.4331
RefSeq NM_001015596
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112869 BT020676 BT026291 BT029889
GenPept AAI12870 AAX08693 ABG81447 ABM06139
RNA Seq Atlas 514191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca